According to the Chief James Pickens Jr, Izzie and George are goners at the end of the season
I can't say I'm surprised at Heigl leaving but TR Knight is a bit of a shocker. He's really done nothing outside of Greys while Heigl has been in a couple of big releases. I'll miss George, but the Izzie storyline has gone cold for me. To be honest, I've never really cared for Izzy's character or storyline, but I did like George as a character. Looks like big changes are afoot at Seattle Grace.
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